Belotecan-d7 hydrochloride(Synonyms: 盐酸贝洛替康 d7 (盐酸盐))

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Belotecan-d7 hydrochloride (Synonyms: 盐酸贝洛替康 d7 (盐酸盐))

Belotecan-d7 hydrochloride 是 Belotecan hydrochloride 的氘代物。Belotecan hydrochloride (CKD-602 hydrochloride) 是拓扑异构酶 I (Topoisomerase I) 抑制剂，是一种合成的喜树碱衍生物。

Belotecan-d7 hydrochloride(Synonyms: 盐酸贝洛替康 d7 (盐酸盐))

Belotecan-d7 hydrochloride Chemical Structure

CAS No. : 1346598-22-8

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生物活性

Belotecan-d7 hydrochloride is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

477.00

Formula

C25H21D7ClN3O4
CAS 号

1346598-22-8
中文名称

盐酸贝洛替康 d7 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Kim YK, et al. Anticancer effects of CKD-602 (Camtobell?) via G2/M phase arrest in oral squamous cell carcinoma cell lines. Oncol Lett. 2015 Jan;9(1):136-142.

    [3]. Kim YY, et al. CKD-602, a camptothecin derivative, inhibits proliferation and induces apoptosis in glioma cell lines. Oncol Rep. 2009 Jun;21(6):1413-9.

    [4]. Kim CY, et al. Antitumor activity of CKD-602, a camptothecin derivative, in a mouse glioma model. J Clin Neurosci. 2012 Feb;19(2):301-5.

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