Theophylline-d6(Synonyms: 1,3-Dimethylxanthine-d6; Theo-24-d6)

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Theophylline-d6 (Synonyms: 1,3-Dimethylxanthine-d6; Theo-24-d6)

Theophylline-d6 (1,3-Dimethylxanthine-d6) 是 Theophylline 的氘代物。Theophylline是非选择性的磷酸二酯酶 (PDE)抑制剂，腺苷受体阻断剂，和组蛋白脱乙酰酶 (HDAC)活化剂。

Theophylline-d6(Synonyms: 1,3-Dimethylxanthine-d6; Theo-24-d6)

Theophylline-d6 Chemical Structure

CAS No. : 117490-39-8

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生物活性

Theophylline-d6 (1,3-Dimethylxanthine-d6) is the deuterium labeled Theophylline. Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

186.20

Formula

C7H2D6N4O2
CAS 号

117490-39-8
中文名称

茶碱 d6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Deree J, et al. Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition. Clinics (Sao Paulo). 2008 Jun;63(3):321-8.

    [3]. Marques LJ, et al. Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages. Am J Respir Crit Care Med. 1999 Feb;159(2):508-11.

    [4]. Daly JW, et al. Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63.

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