Antitumor agent-23

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Antitumor agent-23 

Antitumor agent-23 是一种有效的抗肿瘤剂，对淋巴瘤细胞系 GRANTA-519，KARPAS-422，KARPAS-299，RAMOS，DAUDI 和 RAJI 的 GI50 分别为 38，48，5，27，80 和 28 nM。

Antitumor agent-23

Antitumor agent-23 Chemical Structure

CAS No. : 2355185-12-3

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生物活性

Antitumor agent-23 is a potent anti-cancer agent with GI50s of 38, 48, 5, 27, 80, and 28 nM for lymphoma cell line GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI, respectively. Antitumoral activity[1].

体外研究
(In Vitro)

Antitumor agent-23 (0.001-100 μM; 5 days) inhibits lymphoma cells proliferation[1].
Antitumor agent-23 (2-70 nM; 72 hours) induces p53 protein expression and p53 lysine 382 acetylation (K382Ac-p53) in HPV-positive cervical cancer cell[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Lymphoma cell line GRANTA-519, KARPAS-422,KARPAS-299, RAMOS, DAUDI, RAJI
Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 5 days
Result: The GI50s of 38, 48, 5, 27, 80, 28 nM for GRANTA-519, KARPAS-422,KARPAS-299, RAMOS, DAUDI, RAJI cells, respectively.

Western Blot Analysis[1]

Cell Line: HPV16-positive cervical cancer cell line (CaSki cell)
Concentration: 2, 7, 20, and 70 nM
Incubation Time: 72 hours
Result: Induction of p53 protein above baseline was evident at 7 nM already, acetylation of p53 lysine 382 was detectable at 20 nM.

分子量

506.72

Formula

C28H50N4O4
CAS 号

2355185-12-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Marc Labelle, et al. 1 -(piperidinocarbonylmethyl)-2-oxopiperazine derivatives for treating cancer. WO2019118973A1.

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