Cabazitaxel-d6(Synonyms: XRP6258-d6; RPR-116258A-d6; taxoid XRP6258-d6)

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Cabazitaxel-d6 (Synonyms: XRP6258-d6; RPR-116258A-d6; taxoid XRP6258-d6)

Cabazitaxel-d6 (XRP6258-d6) 是 Cabazitaxel 的氘代物。Cabazitaxel 是天然紫杉烷脱乙酰基巴卡丁III 的半合成衍生物，具有显著的抗肿瘤功效。

Cabazitaxel-d6(Synonyms: XRP6258-d6; RPR-116258A-d6; taxoid XRP6258-d6)

Cabazitaxel-d6 Chemical Structure

CAS No. : 1383561-29-2

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生物活性

Cabazitaxel-d6 (XRP6258-d6) is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

841.97

Formula

C45H51D6NO14
CAS 号

1383561-29-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Tai X, et al. Cabazitaxel and indocyanine green co-delivery tumor-targeting nanoparticle for improved antitumor efficacy and minimized drug toxicity. J Drug Target. 2016 Sep 9:1-29.

    [3]. Gdowski AS, et al. Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. Nanomedicine (Lond). 2017 Sep;12(17):2083-2095.

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