AG6033

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

AG6033 

AG6033是一种潜在的新型CRBN调节剂。AG6033通过调控CRBN与多种抗肿瘤靶蛋白的相互作用抑制多种肿瘤细胞。AG6033可引起GSPT1和IKZF1的降解，且AG6033诱导CRBN依赖的细胞毒性作用。

AG6033

AG6033 Chemical Structure

CAS No. : 329706-62-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect[1].

IC50 & Target

CRBN

 

体外研究
(In Vitro)

AG6033 (0.064-40 μM, 4 h) has potent inhibition ability against A549[1].
AG6033 (1-10 μM, 24 h) significantly promotes apoptosis of A549 cells in a dose-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: A549 cells[1]
Concentration: 0.064 μM, 0.32 μM, 1.6 μM, 8 μM, and 40 μM
Incubation Time: 4 h
Result: Exhibited potent inhibitory ability against A549, with an IC50 of 0.853 μM.

Apoptosis Analysis

Cell Line: A549 cells[1]
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 24 h
Result: Significantly promoted apoptosis of A549 cells in a dose-dependent manner, and the proportion of late apoptotic cells were 5.39%, 22.0%, and 29.1%, respectively.

分子量

517.53

Formula

C30H23N5O4
CAS 号

329706-62-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xiong F, Kong L, Chen L, et al. Discovery of potential novel CRBN modulators by virtual screening and bioassay. Eur J Med Chem. 2022 Apr 5;236:114355.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务