上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
XPO1-IN-1
XPO1-IN-1 (compound D4) 是一种口服有效的 XPO1 抑制剂, 其在 MM.1S 细胞中的 IC50 为 24 nM。XPO1-IN-1 能有效诱导细胞凋亡和细胞周期阻滞。XPO1-IN-1 具有良好的代谢稳定性和药代动力学性质。XPO1-IN-1 可用于多发性骨髓瘤的研究。
XPO1-IN-1 Chemical Structure
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生物活性 |
XPO1-IN-1 (compound D4) is an orally active and potent XPO1 inhibitor, with an IC50 of 24 nM in MM.1S cell. XPO1-IN-1 can efficiently induce cell apoptosis and cell cycle arrest. XPO1-IN-1 displays favorable metabolic stability and pharmacokinetic properties. XPO1-IN-1 can be used for multiple myeloma (MM) research[1]. |
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IC50 & Target |
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体外研究 (In Vitro) |
XPO1-IN-1 (compound D4) (24 h) shows high anti-proliferation efficacy in MM.1S cell and lymphomatous cell lines[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay
Cell Cycle Analysis
Apoptosis Analysis
Immunofluorescence
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体内研究 (In Vivo) |
XPO1-IN-1 (compound D4) (Sprague Dawley rats; 10 mg/kg, IG; 1 mg/kg, IV; once) shows a good pharmacokinetic properties[1]. Pharmacokinetic Parameters of XPO1-IN-1 in SD rats[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
519.42 |
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Formula |
C20H15F6N5O3S |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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