Chaetominine(Synonyms: (-)-Chaetominine)

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Chaetominine (Synonyms: (-)-Chaetominine)

Chaetominine 是一种生物碱代谢物。Chaetominine 对人白血病K562和结肠癌SW1116细胞株具有细胞毒性。Chaetominine 通过抑制 K562/Adr 人白血病细胞中 PI3K/Akt/Nrf2 信号通路来降低 MRP1 介导的耐药性。

Chaetominine(Synonyms: (-)-Chaetominine)

Chaetominine Chemical Structure

CAS No. : 918659-56-0

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生物活性

Chaetominine is an alkaloidal metabolite. Chaetominine has cytotoxicity against human leukemia K562 and colon cancer SW1116 cell lines. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells[1][2].

IC50 & Target

PI3K, Akt, Nrf2[2]
分子量

402.40

Formula

C22H18N4O4
CAS 号

918659-56-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jiao RH, et al. Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015. Org Lett.

    [2]. Yao J, et al. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells. Biochem Biophys Res Commun. 2016;473(4):867-873.

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