Zn(BQTC)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Zn(BQTC) 

Zn(BQTC) 是一种高效的线粒体 DNA (mtDNA) 和核 DNA (nDNA) 抑制剂。Zn(BQTC) 对 mtDNA 和 nDNA 造成严重损伤，继而破坏线粒体和核功能。Zn(BQTC) 促进 DNA 损伤诱导的细胞凋亡信号通路。Zn(BQTC) 对 A549R 细胞具有选择抗增殖活性。Zn(BQTC) 可用于抗癌研究。

Zn(BQTC)

Zn(BQTC) Chemical Structure

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生物活性

Zn(BQTC) is a highly potent mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) inhibitor. Zn(BQTC) causes severe damage to the mtDNA and nDNA, sequentially disruptes mitochondrial and nuclear functions. Zn(BQTC) promotes the DNA damage-induced apoptotic signaling pathway. Zn(BQTC) has selectively antiproliferative activity against A549R cells. Zn(BQTC) can be used for researching anticancer[1].

IC50 & Target

IC50: 10 nM in A549R cells[1]
体外研究
(In Vitro)

Zn(BQTC) (0-100 μM; 6 hours) exhibits highly and selectively antiproliferative activity against A549R with an IC50 of 10 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: A549R, A549 and HL-7702[1]
Concentration: 0-100 μM
Incubation Time: 6 hours
Result: Exhibited potent antiproliferative activity against A549R and A549 cells with IC50s of 10 nM and 11.59 μM, but low activity against HL-7702 with an IC50 over 100 μM.

分子量

650.92

Formula

C30H36Cl2N5O3Zn
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wang ZF, et al. Novel bifluorescent Zn(II)-cryptolepine-cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells [published online ahead of print, 2022 Apr 30]. Eur J Med Chem. 2022;238:114418.

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