Tubulin/MMP-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tubulin/MMP-IN-1 

Tubulin/MMP-IN-1 (compound 15g) 是一种有效的 tubulin 和 MMP 抑制剂。Tubulin/MMP-IN-1具有研究癌症疾病的潜力。Tubulin/MMP-IN-1 抑制微管蛋白聚合，诱导细胞周期停滞在 G2/M 期，导致 HepG2 细胞产生反应性氧化应激 (ROS)，并通过线粒体依赖性凋亡途径导致细胞凋亡[ 1]。

Tubulin/MMP-IN-1

Tubulin/MMP-IN-1 Chemical Structure

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生物活性

Tubulin/MMP-IN-1 (compound 15g) is a potent inhibitor of tubulin and MMP. Tubulin/MMP-IN-1 has the potential for the research of cancer diseases. Tubulin/MMP-IN-1 suppresses tubulin polymerization, induces cell cycle arrest at the G2/M phase, leads to reactive oxidative stress (ROS) generation of HepG2 cells, and results in apoptosis by the mitochondrial-dependent apoptotic pathway[1].

分子量

689.73

Formula

C38H44NO9P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yang L, et al. Dual-functional antitumor conjugates improving the anti-metastasis effect of combretastatin A4 by targeting tubulin polymerization and matrix metalloproteinases [published online ahead of print, 2022 May 5]. Eur J Med Chem. 2022;238:114439.

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