P-gp modulator 2

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P-gp modulator 2 

P-gp modulator 2 (Compound 27) 是一种有效的竞争性和变构性 P-glycoprotein (P-gp) 调节剂。

P-gp modulator 2

P-gp modulator 2 Chemical Structure

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生物活性

P-gp modulator 2 (Compound 27) is a potent, competitive, allosteric P-glycoprotein (P-gp) modulator[1].

体外研究
(In Vitro)

P-gp modulator 2 (Compound 27) shows cytotoxicity on L5178Y parental (L5178Y-PAR) and human ABCB1-gene transfected (L5178Y-MDR) mouse T-lymphoma cells with IC50 values of 8.0 ± 1.1 and 10.7 ± 1.1 µM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

470.32

Formula

C22H20BrN3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ferreira RJ, et al. Nitrogen-containing naringenin derivatives for reversing multidrug resistance in cancer. Bioorg Med Chem. 2020 Dec 1;28(23):115798.

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