VEGFR-2/BRAF-IN-1 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

VEGFR-2/BRAF-IN-1

VEGFR-2/BRAF-IN-1 (Compound 4b) 是一种 VEGFR-2 和 BRAF 双重抑制剂，对 VEGFR-2、BRAF^V600E 和 BRAF^WT 的 IC₅₀ 分别为 0.049、0.063 和 0.005 µM。VEGFR-2/BRAF-IN-1 诱导细胞凋亡，在 G1/S 期阻滞细胞周期。

VEGFR-2/BRAF-IN-1 Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

VEGFR-2/BRAF-IN-1 (Compound 4b) is a dual VEGFR-2 and BRAF kinases inhibitor with IC₅₀ values of 0.049, 0.063 and 0.005 µM against VEGFR-2, BRAF^V600E and BRAF^WT, respectively. VEGFR-2/BRAF-IN-1 induces apoptosis and arrests the cell cycle mainly in the G1/S phase^[1].

IC₅₀ & Target

VEGFR2

0.049 μM (IC₅₀)

BRaf^V600E

0.063 μM (IC₅₀)

BRAF^WT

0.005 μM (IC₅₀)

分子量

642.50

Formula

C₂₆H₂₀Cl₂F₃N₅O₃S₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Hassan RA, et al. Novel antiproliferative agents bearing substituted thieno[2,3-d]pyrimidine scaffold as dual VEGFR-2 and BRAF kinases inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2022 May 10;125:105861.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务