TRK/ALK-IN-1 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TRK/ALK-IN-1

TRK/ALK-IN-1 (compound 21) 是一种有效的 TRK 和 ALK 双重抑制剂。TRK/ALK-IN-1 在酶促测定中与抗增殖活性非常吻合，对 TRKA、ALKIC₅₀ 值分别为 2.2、9.3 和 38 nM< sup>WT 和 ALK^L1196M。TRK/ALK-IN-1具有研究癌症疾病的潜力。

TRK/ALK-IN-1 Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	TRK/ALK-IN-1 (compound 21) is a potent and dual inhibitor of TRK and ALK. TRK/ALK-IN-1 in the enzymatic assays is in good accordance with anti-proliferative activity with IC₅₀ values of 2.2, 9.3 and 38 nM towards TRKA, ALK^WT and ALK^L1196M, respectively. TRK/ALK-IN-1 has the potential for the research of cancer diseases^[1].
分子量	657.18
Formula	C₃₁H₃₅ClF₂N₈O₂S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Li T, et al. Discovery of novel 2-phenylamino-4-prolylpyrimidine derivatives as TRK/ALK dual inhibitors with promising antitumor effects. Bioorg Med Chem. 2021 Oct 1;47:116396.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务