MET kinase-IN-3 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

MET kinase-IN-3

MET kinase-IN-3 (compound 8) 是一种口服有效的 MET 抑制剂，其 IC₅₀ 为9.8 nM。MET kinase-IN-3 对癌细胞具有良好的广谱抗增殖活性。

MET kinase-IN-3 Chemical Structure

CAS No. : 1446324-02-2

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生物活性

MET kinase-IN-3 (compound 8) is an orally active and potent MET inhibitor, with an IC₅₀ of 9.8 nM. MET kinase-IN-3 shows good and broad-spectrum antiproliferative activity against cancer cell lines^[1].

IC₅₀ & Target

MET

9.8 nM (IC₅₀)

VEGFR2

68 nM (IC₅₀)

分子量

491.88

Formula

C₂₅H₁₆ClF₂N₅O₂

CAS 号

1446324-02-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wang MS, et al. Synthesis and biological evaluation of new MET inhibitors with 1,6-naphthyridinone scaffold. Eur J Med Chem. 2020 Jan 1;185:111803.

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