hCAII-IN-2

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hCAII-IN-2 

hCAII-IN-2 (Compound 11f) 是一种胞质型人碳酸酐酶 (hCA) 抑制剂,对 hCA IhCA IIhCA IXhCA XIIKi 分别为 261.4、3.8、19.6 和 45.2 nM

hCAII-IN-2

hCAII-IN-2 Chemical Structure

CAS No. : 2408599-78-8

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生物活性

hCAII-IN-2 (Compound 11f) is a cytosolic human carbonic anhydrase (hCA) inhibitor with Ki values of 261.4, 3.8, 19.6 and 45.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively[1].

IC50 & Target

Ki: 3.8 nM (hCA II), 19.6 nM (hCA IX), 45.2 nM (hCA XII), 261.4 nM (hCA I)[1]

分子量

519.96

Formula

C25H18ClN5O4S

CAS 号

2408599-78-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Khalil OM, et al. Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases. Eur J Med Chem. 2020 Feb 15;188:112021.

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