BRAF V600E/CRAF-IN-2 | whatman (沃特曼)

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BRAF V600E/CRAF-IN-2

BRAF V600E/CRAF-IN-2 (Compound 9c) 是一种有效的 BRAF ^V600E/CRAF 抑制剂，具有 IC₅₀s 分别为 0.888 和 0.229 μM。BRAF V600E/CRAF-IN-2 在 HCT-116 结肠癌细胞的 G0/G1 期触发细胞凋亡和细胞周期停滞。BRAF V600E/CRAF-IN-2具有研究癌症疾病的潜力。

BRAF V600E/CRAF-IN-2 Chemical Structure

CAS No. : 2499499-62-4

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生物活性	BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF ^V600E/CRAF with IC₅₀s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases^[1].
分子量	549.59
Formula	C₃₀H₃₀F₃N₅O₂
CAS 号	2499499-62-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. El-Damasy AK,et al. 2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments. Eur J Med Chem. 2020 Dec 15;208:112756.

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