hCAIX-IN-6

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

hCAIX-IN-6 

化合物6b和14g对肿瘤相关亚型hCA IX表现出显着的抑制作用，具有低纳摩尔效力，而6k对hCA XII有效。化合物6b，14g和6k可以被认为是基于新作用机制的未来癌症治疗药物发展的先导分子。

hCAIX-IN-6

hCAIX-IN-6 Chemical Structure

CAS No. : 2451479-86-8

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生物活性

Compounds 6B and 14g showed significant inhibitory effect on tumor related subtype HCA IX with low nanomolar potency, while 6K was effective on HCA XII. Compounds 6B, 14g and 6K can be considered as the leading molecules for the development of future cancer therapeutic drugs based on new mechanisms of action.

分子量

352.36

Formula

C18H12N2O4S
CAS 号

2451479-86-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Swain B,et al. New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorg Med Chem. 2020 Aug 1;28(15):115586.

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