Antiproliferative against-8

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Antiproliferative against-8 

Antiproliferative against-8 (compound 8f) 是一种有效的抗增殖剂。Antiproliferative against-8 对癌细胞 MCF-7、MDA-MB-231、HCT-116 和 FR-2 具有抗增殖活性，IC50 分别为 3.5 μM、15.54 μM、30.43 μM 和 34.8 μM。Antiproliferative against-8 可促进 ROS 产生，诱导细胞凋亡 (apoptosis)。

Antiproliferative against-8

Antiproliferative against-8 Chemical Structure

CAS No. : 2497687-47-3

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生物活性

Antiproliferative against-8 (compound 8f) is a potent anti-proliferative agent. Antiproliferative against-8 has antiproliferative activity against cancer cell lines MCF-7, MDA-MB-231, HCT-116 and FR-2 with IC50s of 3.5 μM, 15.54 μM, 30.43 μM and 34.8 μM, respectively. Antiproliferative against-8 can increase ROS production and induce apoptosis[1].

IC50 & Target

IC50: 3.5 μM (MCF-7), 15.54 μM (MDA-MB-231), 30.43 μM (HCT-116), 34.8 μM (FR-2)[1]
分子量

440.58

Formula

C28H32N4O
CAS 号

2497687-47-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Dheer D,et al.Design, synthesis and comparative analysis of triphenyl-1,2,3-triazoles as anti-proliferative agents. Eur J Med Chem. 2020 Dec 1;207:112813.

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