HDAC6-IN-8

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

HDAC6-IN-8 

通过修饰Cap基团设计并合成了多种化合物，通过酶抑制试验表明，化合物12c发挥了广谱酶抑制活性，化合物9m和9q更倾向于抑制HDAC6，在代表性亚型中表现出一定的选择性抑制活性。

HDAC6-IN-8

HDAC6-IN-8 Chemical Structure

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生物活性

A variety of compounds were designed and synthesized by modifying cap groups. The enzyme inhibition test showed that compound 12C had broad-spectrum enzyme inhibitory activity, and compounds 9m and 9q were more inclined to inhibit HDAC6, showing a certain selective inhibitory activity among the representative subtypes.

分子量

510.32

Formula

C23H17BrFN5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li X,et al. Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategy. Bioorg Chem. 2022 May 24;125:105874.

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