AKR1C3-IN-8

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

AKR1C3-IN-8 

AKR1C3-IN-8 (Compound 5) 是一种有效的、选择性的 AKR1C3 抑制剂，IC50 为 0.069 μM。AKR1C3-IN-8 具有抗肿瘤活性。

AKR1C3-IN-8

AKR1C3-IN-8 Chemical Structure

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生物活性

AKR1C3-IN-8 (Compound 5) is a potent, selective AKR1C3 inhibitor with an IC50 of 0.069 μM. AKR1C3-IN-8 shows antitumor activity[1].

IC50 & Target

IC50: 0.069 μM (AKR1C3)[1]
体外研究
(In Vitro)

AKR1C3-IN-8 (Compound 5) shows antiproliferative activity with an IC50 of 52.06 ± 0.99 μM against prostate cancer cell line 22rv1[1].
AKR1C3-IN-8 (0-50 μM) inhibits PSA expression and testosterone production on 22RV1 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

400.43

Formula

C23H20N4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Pippione AC, et al. New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold. Eur J Med Chem. 2022 Jul 5;237:114366.

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