Androgen receptor antagonist 4 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Androgen receptor antagonist 4

Androgen receptor antagonist 4 (Compound AT2) 是一种雄激素受体 (androgen receptor (AR)) 拮抗剂，IC₅₀ 值为 0.15 μM。Androgen receptor antagonist 4 能有效拮抗 AR 转录活性，抑制 AR 下游靶基因，阻断 DHT 诱导的 AR 核易位。Androgen receptor antagonist 4 具有抗癌活性。

Androgen receptor antagonist 4 Chemical Structure

CAS No. : 354815-43-3

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Androgen receptor antagonist 4 (Compound AT2) is an androgen receptor (AR) antagonist with an IC₅₀ of 0.15 μM. Androgen receptor antagonist 4 efficiently antagonizes AR transcriptional activity, suppresses downstream target gene of AR, and blocks the DHT-induced AR nuclear translocation. Androgen receptor antagonist 4 shows anticancer activities^[1].
IC₅₀ & Target	IC₅₀: 0.15 μM (Androgen receptor)^[1]
分子量	331.84
Formula	C₂₂H₁₈ClN
CAS 号	354815-43-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Tang Q, et al. Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation. Eur J Med Chem. 2020 Apr 15;192:112156.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务