CAXII-IN-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CAXII-IN-1 

CAXII-IN-1 (Compound 17) 是一种选择性的 CA XII 抑制剂，对 hCA XII 和 hCA IX 的 Ki 值分别为 3.8 nM 和 56.0 nM。CAXII-IN-1 具有抗肿瘤活性。

CAXII-IN-1

CAXII-IN-1 Chemical Structure

CAS No. : 2479918-59-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CAXII-IN-1 (Compound 17) is a selective CA XII inhibitor with Ki values of 3.8 nM and 56.0 nM against hCA XII and hCA IX, respectively. CAXII-IN-1 shows antitumor activity[1].

IC50 & Target

IC50: 3.8 nM (hCA XII), 56.0 nM (hCA IX)[1]
体外研究
(In Vitro)

CAXII-IN-1 (Compound 17) shows cytotoxicity with IC50 values of 20±1, 4.8±0.03 and 14±2 µM against MCF-7, HeLa and A549 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

328.17

Formula

C13H7Cl2NO3S
CAS 号

2479918-59-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Grandāne A, et al. Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. Eur J Med Chem. 2020 Aug 15;200:112300.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务