Tubulin inhibitor 27

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tubulin inhibitor 27 

Tubulin inhibitor 27 (DYT-1) 是一种微管蛋白聚集 (tubulin polymerisation) 抑制剂，IC50 为 25.6 µM。Tubulin inhibitor 27 具有抗血管生成活性和抗肿瘤活性。

Tubulin inhibitor 27

Tubulin inhibitor 27 Chemical Structure

CAS No. : 184579-57-5

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生物活性

Tubulin inhibitor 27 (DYT-1) is a tubulin polymerisation inhibitor with an IC50 of 25.6 µM. Tubulin inhibitor 27 shows anti-angiogenesis and antitumor activities[1].

IC50 & Target

IC50: 25.6 µM (Tubulin polymerisation)[1]
体外研究
(In Vitro)

Tubulin inhibitor 27 (DYT-1) shows anti-proliferation activity with IC50 values of 6.2 µM and 7.9 µM against K562 and Jurkat, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Tubulin inhibitor 27 (DYT-1) shows anti-angiogenesis activity in Zebrafish with an IC50 of 38.4 µM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

349.38

Formula

C21H19NO4
CAS 号

184579-57-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yao Y, et al. Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):652-665.

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