Antiproliferative against-7

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Antiproliferative against-7 

Antiproliferative against-7 (compound 8a) 是一种有效的抗肿瘤剂。Antiproliferative against-7 对癌细胞系 HCT116、MCF-7、H460 和非肿瘤非整倍体永生角质细胞 HaCaT 具有抗增殖活性，GI50 分别为 0.5 μM、2 μM、0.7 μM 和 3.5 μM。

Antiproliferative against-7

Antiproliferative against-7 Chemical Structure

CAS No. : 2389016-82-2

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生物活性

Antiproliferative against-7 (compound 8a) is a potent antitumor agent. Antiproliferative against-7 has antiproliferative activity against cancer cell lines HCT116, MCF-7, H460 and non-tumor aneuploid immortal keratinocyte HaCaT cells with GI50s of 0.5 μM, 2 μM, 0.7 μM and 3.5 μM, respectively[1].

IC50 & Target

GI50: 0.5 μM (HCT116), 2 μM (MCF-7), 0.7 μM (H460), 3.5 μM (HaCaT)[1]
分子量

404.83

Formula

C21H14ClFN6
CAS 号

2389016-82-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Meščić Macan A, et al. Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis-(1,2,3-triazolyl)-appended benzimidazo[1,2-a]quinoline derivatives. Eur J Med Chem. 2020;185:111845.

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