Anticancer agent 54

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Anticancer agent 54 

Anticancer agent 54 是一种有效的抗癌剂。Anticancer agent 54 显示出抗增殖活性。 Anticancer agent 54 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G0/G1 期。Anticancer agent 54 的抗癌活性取决于 DNA 嵌入和 ROS 生成。

Anticancer agent 54

Anticancer agent 54 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation[1].

体外研究
(In Vitro)

Anticancer agent 54 (compound L) (0-25 µM; 72 h) shows antiproliferative activity with IC50s of 0.04, 0.44, 0.27, 0.14, 0.75, 20.83 µM for MCF-7, PANC-1, HCT116, U-251, A549, NHDF (normal human fifibroblast) clls, respectively[1].
Anticancer agent 54 (1, 2.5, 5 µM; 24 h) induces cell cycle arrest at G0/G1 phases and apoptosis in a concentration-dependent manner[1].
Anticancer agent 54 (1 µM; 24 h) increases the reactive oxygen species (ROS) level[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 2.5, 5 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G0/G1 phases in a concentration-dependent manner.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 2.5, 5 µM
Incubation Time: 24 h
Result: The level of the apoptotic cells increased from 7.62% to 29.33% and the population of living cells decreased from 92.01% to 55.27% at 5 µM.

分子量

516.68

Formula

C33H36N6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Malarz K,et al.Anticancer activity of 4′-phenyl-2,2′:6′,2″-terpyridines – behind the metal complexation. Eur J Med Chem. 2020 Mar 1;189:112039.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务