SHP2 protein degrader-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SHP2 protein degrader-2 

SHP2 protein degrader-2 (SHP2-D26) 是一种 SHP2 蛋白 PROTAC 降解剂。SHP2 protein degrader-2 可降低各种癌细胞中 SHP2 的表达水平。

SHP2 protein degrader-2

SHP2 protein degrader-2 Chemical Structure

CAS No. : 2740582-16-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells[1].

体外研究
(In Vitro)

SHP2 protein degrader-2 (SHP2-D26) achieves excellent degradation of SHP2 with the DC50 (the concentration where 50% of the protein has been degraded) values of 2.6 nM and 6.0 nM for MV4;11 and KYSE520 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1115.89

Formula

C56H79ClN12O6S2
CAS 号

2740582-16-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Song Y, et al. Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy. J Med Chem. 2022 Feb 24;65(4):3066-3079.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务