FAP-2286

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

FAP-2286 

FAP-2286，一种与放射性核素螯合剂 DOTA 偶联的 FAP 结合肽大环化合物。FAP-2286 对人 FAP 蛋白具有强亲和力，Kd 为 1.1 nM。FAP-2286 是一种肿瘤显像剂，是研究正电子发射断层扫描 (PET) 的有用工具。FAP-2286 具有抗肿瘤活性。

FAP-2286

FAP-2286 Chemical Structure

CAS No. : 2581741-18-4

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生物活性

FAP-2286, a fibroblast activation protein (FAP)-binding peptidic macrocycle coupled to the radionuclide chelator DOTA. FAP-2286 has potent affinity to human FAP protein with a Kd of 1.1 nM. FAP-2286, a tumor imaging agent, is a useful tool for the research of positron emission tomography (PET). FAP-2286 has antitumor activity[1][2].

分子量

1470.77

Formula

C67H99N13O18S3
CAS 号

2581741-18-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Dirk Zboralski, et al. Comparative Biodistribution and Radiotherapeutic Efficacy of the Fibroblast Activation Protein (FAP)–Targeting Agents FAP-2286 and FAPI-46.

    [2]. Richard P Baum, et al. Feasibility, Biodistribution, and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy of Diverse Adenocarcinomas Using 177 Lu-FAP-2286: First-in-Humans Results. J Nucl Med. 2022 Mar;63(3):415-423.

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