Anticancer agent 56

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Anticancer agent 56 

Anticancer agent 56 (compound 4d) 是一种具有类似药物特性的强效抗癌剂，对多种肿瘤细胞系具有抗癌活性 (IC50<3 μm)。anticancer agent 56 诱导细胞周期阻滞在 g2>ROS，上调 BAX，下调 Bcl-2，激活 caspases 3, 7, 9 起到抗癌作用。

Anticancer agent 56

Anticancer agent 56 Chemical Structure

CAS No. : 2241915-59-1

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生物活性

Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with drug-likeness properties, possessing anticancer activity against several cancer cell lines (IC50<3 μm). anticancer agent 56 induces cell cycle arrest at g2>apoptosis pathway. Anticancer agent 56 acts by accumulation of ROS, up regulation of BAX, down regulation of Bcl-2 and activation of caspases 3, 7, 9[1].

IC50 & Target

IC50: 0.64 ± 0.02 μM in Leukemia RPMI-8226, 0.96 ± 0.04 μM in Leukemia SR, 0.84 ± 0.07 μM in Leukemia K-562, 0.69 ± 0.01 μM in Melanoma M14, 0.24 ± 0.01 μM in Breast MCF7, 0.26 ± 0.01 μM in Colon HCT116, 2.95 ± 0.14 μM in Prostate PC3[1]
分子量

383.83

Formula

C20H18ClN3O3
CAS 号

2241915-59-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ashour HF, et al. 1,2,3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226. Eur J Med Chem. 2020;189:112062.

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