LY294002 hydrochloride

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

LY294002 hydrochloride 

LY294002 hydrochloride 是一种有效的广谱 PI3K 抑制剂,对 P110α, P110δP110βIC50 分别为 0.5, 0.57 和 0.97 μM。 IC50值分别为P110α、P110δ和P110β的0.5、0.57和0.97 μM。LY294002 hydrochloride 也能抑制 CK2 ,其 IC50 为 98 nM。LY294002 hydrochloride 可用于胰腺癌研究。

LY294002 hydrochloride

LY294002 hydrochloride Chemical Structure

CAS No. : 934389-88-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

LY294002 hydrochloride 的其他形式现货产品:

LY294002

生物活性

LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC50 values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research[1][2].

IC50 & Target

CK2

0.098 μM (IC50)

CK2α2

3.869 μM (IC50)

分子量

343.80

Formula

C19H18ClNO3

CAS 号

934389-88-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bai R, et al. The effect of PI3K inhibitor LY294002 and gemcitabine hydrochloride combined with ionizing radiation on the formation of vasculogenic mimicry of Panc-1 cells in vitro and in vivo. Neoplasma. 2016;63(1):80-92.

    [2]. Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007 Jun 15;404(3):449-58.

    [3]. Gharbi SI, et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J. 2007 May 15;404(1):15-21.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务