PROTAC IRAK4 degrader-2 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PROTAC IRAK4 degrader-2

PROTAC IRAK4 degrader-2 (Compound 9) 是一种 PROTAC IRAK4 降解剂，在外周血单个核细胞 (PBMC) 中，降解 IRAK4，DC₅₀ 为 151 nM。PROTAC IRAK4 Degrader-2 在 PBMC 细胞中诱导 IRAK4 蛋白水平降低，DC₅₀ 为 36 nM。PROTAC IRAK4 degrader-2 还抑制 PBMC 中多种细胞因子释放。

PROTAC IRAK4 degrader-2 Chemical Structure

CAS No. : 2374122-27-5

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生物活性

PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC₅₀ in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a reduction of IRAK4 protein levels with a DC₅₀ of 36 nM in PBMC cells. PROTAC IRAK4 degrader-2 also leads to the inhibition of multiple cytokines in PBMCs^[1].

体外研究
(In Vitro)

PROTAC IRAK4 degrader-2 (compound 9) (0.01~10 μM; 22 hours; PBMCs) mediated degradation is occurring in a proteasome dependent manner^[1].
PROTAC IRAK4 degrader-2 (compound 9) (0.01~10 μM; 24 hours; PBMCs) induces a reduction of IRAK4 protein levels^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	PBMCs
Concentration:	0.01, 0.03, 0.1, 0.3, 1, 3 and 10 μM
Incubation Time:	22 and 24 hours
Result:	Induced a reduction of IRAK4 protein levels with a DC₅₀ value of 36 nM and IRAK4 PROTAC-mediated degradation was occurring in a proteasome dependent manner.

分子量

1086.28

Formula

C₅₇H₆₈FN₁₁O₈S

CAS 号

2374122-27-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Joao Nunes, et al. Targeting IRAK4 for Degradation with PROTACs. ACS Med Chem Lett. 2019 Jun 14;10(7):1081-1085.

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