Fadrozole hydrochloride hemihydrate(Synonyms: CGS 16949A hemihydrate; (Rac)-FAD286 hydrochloride hemihydrate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Fadrozole hydrochloride hemihydrate (Synonyms: CGS 16949A hemihydrate; (Rac)-FAD286 hydrochloride hemihydrate)

Fadrozole hydrochloride hemihydrate 是一种口服有效的、选择性非甾体芳香化酶 (aromatase) 抑制剂，其 IC50 为 6.4 nM。Fadrozole hydrochloride hemihydrate 抑制雌激素和孕酮的产生，其 IC50 值分别为 0.03 和 120 μM。Fadrozole hydrochloride hemihydrate 可预防自发性肿瘤。Fadrozole hydrochloride hemihydrate 可用于雌激素依赖性疾病和癌症的研究。

Fadrozole hydrochloride hemihydrate(Synonyms: CGS 16949A hemihydrate; (Rac)-FAD286 hydrochloride hemihydrate)

Fadrozole hydrochloride hemihydrate Chemical Structure

CAS No. : 176702-70-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Fadrozole hydrochloride hemihydrate 的其他形式现货产品:

Fadrozole hydrochloride Fadrozole

生物活性

Fadrozole hydrochloride hemihydrate is an orally active, potent, selective and nonsteroidal aromatase inhibitor, with an IC50 of 6.4 nM. Fadrozole hydrochloride hemihydrate inhibits the production of estrogen and progesterone, with IC50 values of 0.03 and 120 μM. Fadrozole hydrochloride hemihydrate shows prevention of spontaneous tumours. Fadrozole hydrochloride hemihydrate can be used for the research of estrogen-dependent disease and cancer[1][2][3].

IC50 & Target

IC50: 6.4 nM (aromatase)[1]
体外研究
(In Vitro)

Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of Fadrozole hydrochloride hemihydrate[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Fadrozole hydrochloride hemihydrate is able to inhibit the aromatase-mediated uterine hypertrophy in immature female rats with an ED50 of 0.03 mg/kg when given orally[1].
Fadrozole hydrochloride hemihydrate prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars distalis adenomas in female rats, and reduces the incidence of spontaneous hepatocellular tumours in male and female rats[2].
Administration of Fadrozole hydrochloride hemihydrate in male and female mice accompanies with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

268.74

Formula

C14H13N3.ClH.1/2H2O
CAS 号

176702-70-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Browne LJ, et al. Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem. 1991 Feb;34(2):725-36.

    [2]. Gunson DE, et al. Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor. Br J Cancer. 1995 Jul;72(1):72-5.

    [3]. Morales-Montor J, et al. Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis. Int J Parasitol. 2002 Oct;32(11):1379-87.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务