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Ezurpimtrostat hydrochloride (Synonyms: GNS561 hydrochloride)
Ezurpimtrostat hydrochloride (compound 2-3) 是一种口服有效的抗纤维化剂。Ezurpimtrostat hydrochloride 能明显减轻 DEN (二乙基亚硝胺)肝硬化大鼠的肝纤维化。Ezurpimtrostat hydrochloride 可用于纤维化、癌症、自噬和CTSB、CTSL 和 CTSD 相关的疾病研究。
Ezurpimtrostat hydrochloride Chemical Structure
CAS No. : 1914148-73-4
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| 生物活性 |
Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases [1]. |
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| 体内研究 (In Vivo) |
Ezurpimtrostat hydrochloride (compound 2-3) (15 mg/kg/day, PO, for 6 weeks) significantly reduces the area of liver fibrosis and the level of collagen fibers deposition (by 41.0%) in DEN cirrhotic rat model[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
459.45 |
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| Formula |
C25H32Cl2N4 |
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| CAS 号 |
1914148-73-4 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 溶解性数据 |
In Vitro:
DMSO : 8.33 mg/mL (18.13 mM; ultrasonic and warming and heat to 60°C) 配制储备液
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| 参考文献 |
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