上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
Abacavir monosulfate (Synonyms: 阿巴卡韦单硫酸盐)
Abacavir monosulfate 是一种竞争性的口服活性核苷逆转录酶（nucleoside reverse transcriptase）抑制剂。 Abacavir monosulfate 可抑制 HIV 的复制。Abacavir monosulfate 在前列腺癌细胞系中显示出抗癌活性。Abacavir monosulfate 可突破血脑屏障，抑制端粒酶（telomerase）活性。
Abacavir monosulfate Chemical Structure
CAS No. : 216699-07-9
| 规格 |
|
是否有货 |
|
| 100 mg |
|
询价 |
|
| 250 mg |
|
询价 |
|
| 500 mg |
|
询价 |
|
* Please select Quantity before adding items.
Abacavir monosulfate 的其他形式现货产品:
Abacavir Abacavir sulfate
| 生物活性 |
Abacavir monosulfate is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir monosulfate can inhibits the replication of HIV. Abacavir monosulfate shows anticancer activity in prostate cancer cell lines. Abacavir monosulfate can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].
|
体外研究
(In Vitro) |
Abacavir (15 and 150 μM, 0-120 h) monosulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines[1].
Abacavir (15 and 150 μM, 18 h) monosulfate significantly reduces cell migration and inhibits cell invasion[1].
Abacavir monsulfate induces fat apoptosis[4].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[1]
| Cell Line: |
PC3, LNCaP and WI-38 |
| Concentration: |
15 and 150 μM |
| Incubation Time: |
0, 24, 48, 72 and 96 h |
| Result: |
Showed a dose-dependent growth inhibition on PC3 and LNCaP. |
Cell Cycle Analysis[1]
| Cell Line: |
PC3 and LNCaP |
| Concentration: |
150 μM |
| Incubation Time: |
0, 18, 24, 48, 72, 96 and 120 h |
| Result: |
Caused a very high accumulation of cells in S phase in PC3 and LNCaP cells, and G2/M phase increment was observed in PC3 cells. |
Cell Migration Assay [1]
| Cell Line: |
PC3 and LNCaP |
| Concentration: |
15 and 150 μM |
| Incubation Time: |
18 h |
| Result: |
Significantly reduced cell migration. |
Cell Invasion Assay[1]
| Cell Line: |
PC3 and LNCaP |
| Concentration: |
15 and 150 μM |
| Incubation Time: |
18 h |
| Result: |
Significantly inhibited cell invision. |
|
体内研究
(In Vivo) |
Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) monosulfate dose-dependently promoted thrombus formation[2].
Abacavir (50 mg/kg/d; i.p.; 14 days) monosulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: |
Male mice (9-weeks old, 22-30 g) – wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2] |
| Dosage: |
2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg |
| Administration: |
Intrascrotal or oral administration for 4 h |
| Result: |
Dose-dependently promoted thrombus formation. |
| Animal Model: |
NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3] |
| Dosage: |
50 mg/kg/d with 0.1 mg/kg/d Decitabine |
| Administration: |
Intraperitoneal injection, daily for 14 days |
| Result: |
Inhibited tumor growth and enhanced mouse survival. |
|
| 分子量 |
|
| Formula |
|
| CAS 号 |
|
| 中文名称 |
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
|
| 参考文献 |
-
[1]. Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5(12):e14221.
[2]. Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218(2):228-233.
[3]. Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23(7):3815.
[4]. McComsey GA, et al. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS. 2005 Jan 3;19(1):15-23.
|
所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务
