5,8,11,14,17,20,23,26-八氧杂-2-氮杂二十九碳二酸 1-(9H-芴-9-基甲基)酯
基本信息
| 产品名称 | 5,8,11,14,17,20,23,26-八氧杂-2-氮杂二十九碳二酸 1-(9H-芴-9-基甲基)酯 |
|---|---|
| 英文名称 | 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid 1-(9H-fluoren-9-ylmethyl) ester |
| 别名 | Fmoc-NH-(PEG)8-CH2CH2COOH；Fmoc-N-amido-dPEG 8-acid；Fmoc-NH-PEG8-acid, Fmoc-N-amido-PEG8-acid, Fmoc-N-amido-PEG8-COOH, Fmoc-PEG-acid；1-(9H-Fluoren-9-ylmethyl) 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioate;1-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino) |
| 英文别名 | Fmoc-NH-(PEG)8-CH2CH2COOH；Fmoc-N-amido-dPEG 8-acid；Fmoc-NH-PEG8-acid, Fmoc-N-amido-PEG8-acid, Fmoc-N-amido-PEG8-COOH, Fmoc-PEG-acid；1-(9H-Fluoren-9-ylmethyl) 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioate;1-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino) |
| 规格或纯度 | 98% |
| 运输条件 | 超低温冰袋运输 |
一般描述
Fmoc-N-amido-dPEG8-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atom dPEG spacer allows the introduction of a medium-length, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the Fmoc-N-amido-dPEGn-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series.
application：
Fmoc-NH-PEG8-CH2CH2COOH is used in synthesis of protein-antiviral compound conjugates.
Fmoc-N-amido-dPEG8-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atom dPEG spacer allows the introduction of a medium-length, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the Fmoc-N-amido-dPEGn-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series.
application：
Fmoc-NH-PEG8-CH2CH2COOH is used in synthesis of protein-antiviral compound conjugates.
相关属性
| CAS编号 | 756526-02-0 |
|---|---|
| 储存温度 | -20°C储存 |
| 分子量 | 663.76 |
| 分子式 | C34H49NO12 |
| 品牌 | Jinpan |
| PubChem CID | 51340975 |