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名称 | Neuropeptide W-30 (human) |
编码 | [383415-80-3] |
别名 | Neuropeptide W-30 (human) |
纯度 | 80%,90%,95%,98%,99% |
重量 | 1mg,5mg,10mg,50mg,100mg,1g |
序列(单字母缩写) | WYKHVASPRYHTVGRAAGLLMGLRRSPYLW |
序列(三字母缩写) | H-Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Met-Gly-Leu-Arg-Arg-Ser-Pro-Tyr-Leu-Trp-OH (trifluoroacetate salt) |
基本描述 | This peptide was recently identified as the endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8 which are expressed in the central nervous system. NPW-30 activated and bound to both GPR7 and GPR8 at similar effective doses. Intracerebroventricular administration of NPW in rats resulted in an increased food intake and stimulation of prolactin release indicating that NPW acts as a mediator of the central control of feeding and the neuroendocrine system. |
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分子量 | 3543.17 |
化学式 | C165H249N49O37S1 |
存储条件 | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
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Reference | Y.Shimomura et al., J. Biol. Chem., 277, 35826 (2002) S.Brezillon et al., J. Biol. Chem., 278, 776 (2003) H.Tanaka et al., Proc. Natl. Acad. Sci. USA, 100, 6251 (2003) |
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