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名称	[Lys(Me2)370]-p53 (361-380); p53K370Me2
编码
别名	[Lys(Me2)370]-p53 (361-380); p53K370Me2
纯度	80%，90%，95%，98%，99%
重量	1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写）	GSRAHSSHL-K(Me2)-SKKGQSTSRH
序列（三字母缩写）	H-Gly-Ser-Arg-Ala-His-Ser-Ser-His-Leu-Lys(Me2)-Ser-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-OH (trifluoroacetate salt)
基本描述	This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with dimethylation at Lys372 and additional KGW residues on its N-terminus. Methylation at Lys372 activates p53 and induces upregulation of target gene p21. Methylation at Lys372 also inhibits Lys370 methylation by interfering with Smyd2, a lysine methyltransferase, and p53 interaction. Lys 370 methylation reduces p53 transcriptional targets.
溶解度
分子量	2204.4
化学式
存储条件	Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents
Figures
Reference	Egorova, K. Biochem 75, 535 (2010)
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N端
化学桥