SGN-2FF

发表于由

SGN-2FF  纯度: ≥99.0%

SGN-2FF 是一种有效的，具有口服活性的岩藻糖基化抑制剂，抑制岩藻糖基转移酶 (fucosyltransferase) 的活性，具有抗肿瘤活性。

SGN-2FF

SGN-2FF Chemical Structure

CAS No. : 2089647-47-0

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥1980 In-stock
5 mg ￥1800 In-stock
10 mg ￥2880 In-stock
25 mg ￥5760 In-stock
50 mg ￥9200 In-stock
100 mg ￥14750 In-stock
200 mg   询价  
500 mg   询价  

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SGN-2FF 相关产品

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生物活性

SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity[1].

IC50 & Target

Fucosyltransferase[1]
体外研究
(In Vitro)

SGN-2FF (2-Fluorofucose) is an inhibitor of fucosylation, inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of afucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

SGN-2FF exhibits antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

166.15

Formula

C6H11FO4
CAS 号

2089647-47-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (300.93 mM; Need ultrasonic)

H2O : 36.67 mg/mL (220.70 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.0187 mL 30.0933 mL 60.1866 mL
5 mM 1.2037 mL 6.0187 mL 12.0373 mL
10 mM 0.6019 mL 3.0093 mL 6.0187 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Stephen C. Alley, et al. Abstract DDT02-02: SGN-2FF: A novel small molecule inhibitor of fucosylation with preclinical antitumor activity through multiple immune mechanisms. Cancer Res 2017;77(13 Suppl).

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