上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Tolcapone (Synonyms: 托卡朋; Ro 40-7592) 纯度: 99.74%
Tolcapone (Ro 40-7592) 是一种选择性,有效的,具有口服活性的外周和中枢 COMT 抑制剂,在肝脏中对 COMT 的 IC50 为 773 nM。Tolcapone 还是一种 α-syn 和 Aβ42 寡聚和原纤维形成的有效抑制剂。Tolcapone 诱导氧化应激导致神经母细胞瘤细胞凋亡(apoptosis) 和抑制肿瘤生长。
Tolcapone Chemical Structure
CAS No. : 134308-13-7
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥567 | In-stock | |
10 mg | ¥515 | In-stock | |
50 mg | ¥1252 | In-stock | |
100 mg | ¥1626 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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Tolcapone 相关产品
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生物活性 |
Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver[1]. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis[2]. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma[3]. |
IC50 & Target |
COMT[1] |
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体外研究 (In Vitro) |
Tolcapone is cytotoxic to neuroblastoma (NB) cells with IC50 values ranging from 32.27 μM for SMS-KCNR cells to 219.8 μM for MGT9-102-08 primary cells[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[3]
Cell Viability Assay[3]
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体内研究 (In Vivo) |
Tolcapone (125 mg/kg; orally) inhibits tumor growth and prolongs survival in vivo. There are no adverse events or differences in weight or behavior noted in the mice[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
273.24 |
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Formula |
C14H11NO5 |
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CAS 号 |
134308-13-7 |
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中文名称 |
托卡朋 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (365.98 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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