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Cysteamine hydrochloride (Synonyms: 半胱胺盐酸盐; 2-Aminoethanethiol hydrochloride; 2-Mercaptoethylamine hydrochloride) 纯度: ≥98.0%
Cysteamine hydrochloride (2-Aminoethanethiol hydrochloride) 是一种可口服的,用于肾病型胱胺酸症得小分子药物,也可作为抗氧化剂。
Cysteamine hydrochloride Chemical Structure
CAS No. : 156-57-0
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥500 | In-stock | |
500 mg | ¥400 | In-stock | |
5 g | ¥500 | In-stock | |
10 g | 询价 | ||
50 g | 询价 |
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生物活性 |
Cysteamine hydrochloride (2-Aminoethanethiol hydrochloride) is an orally active agent for the treatment of nephropathic cystinosis and an antioxidant. |
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IC50 & Target[1][2] |
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体外研究 (In Vitro) |
Cysteamine hydrochloride (2-Aminoethanethiol hydrochloride) has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine hydrochloride administration. Cysteamine hydrochloride has antioxidant properties as a result of increasing glutathione production. Cysteamine hydrochloride is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine hydrochloride increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine hydrochloride exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine hydrochloride treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine hydrochloride to doxorubicin results in a dramatic increase in cell death[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
113.61 |
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Formula |
C2H8ClNS |
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CAS 号 |
156-57-0 |
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中文名称 |
半胱胺盐酸盐;α-巯基乙胺盐酸盐 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
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溶解性数据 |
In Vitro:
DMSO : 250 mg/mL (2200.51 mM; Need ultrasonic) H2O : ≥ 50 mg/mL (440.10 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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