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Cot inhibitor-2 纯度: 99.22%
Cot inhibitor-2 是一种有效的,选择性的,具有口服活性的 cot (Tpl2/MAP3K8) 抑制剂,IC50 为 1.6 nM。Cot inhibitor-2 抑制 LPS 刺激的人全血中 TNF-α 的产生,IC50 为 0.3 μM。
Cot inhibitor-2 Chemical Structure
CAS No. : 915363-56-3
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥2730 | In-stock | |
2 mg | ¥1400 | In-stock | |
5 mg | ¥2300 | In-stock | |
10 mg | ¥3700 | In-stock | |
25 mg | ¥7600 | In-stock | |
50 mg | ¥13500 | In-stock | |
100 mg | ¥22000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
Cot inhibitor-2 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Immunology/Inflammation Compound Library
- Kinase Inhibitor Library
- MAPK Compound Library
- Anti-Cancer Compound Library
- Oxygen Sensing Compound Library
- Orally Active Compound Library
- Targeted Diversity Library
生物活性 |
Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM[1]. |
IC50 & Target |
COT/Tpl2[1] |
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体内研究 (In Vivo) |
Cot inhibitor-2 (compound 34) is orally administered in rats with 100 mg/kg dosing and showed a Cmax of 517 ng/mL (0.89 μM) and AUC of 4841 ng•h/mL. Cot inhibitor-2 is tested in the LPS-induced TNF-α production model in female Sprague-Dawley rats. With a 25 mg/kg po dose, Cot inhibitor-2 inhibits LPS-induced TNF-α production by 83%[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
539.43 |
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Formula |
C26H25Cl2FN8 |
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CAS 号 |
915363-56-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 40 mg/mL (74.15 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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