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dTRIM24 纯度: 99.69%
dTRIM24 是一种选择性的双功能基于 PROTAC 技术的 TRIM24 降解剂,由von Hippel-Lindau 和TRIM24 两者配体组成。
dTRIM24 Chemical Structure
CAS No. : 2170695-14-2
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥3500 | In-stock | |
10 mg | ¥5500 | In-stock | |
25 mg | ¥13200 | In-stock | |
50 mg | ¥24500 | In-stock | |
100 mg | ¥42000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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dTRIM24 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
生物活性 |
dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24. |
IC50 & Target |
TRIM24[2]. |
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体外研究 (In Vitro) |
dTRIM24 is a degrader of TRIM24 bromodomain. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24. The anti-proliferative consequences of chemical degradation versus inhibition of TRIM24 are assessed. Growth over time is determined for MOLM-13 cells treated with dTRIM24, IACS-9571, VL-269, and eTRIM24. dTRIM24 suppresses growth to a greater extent than does IACS-9571, accompanied by apoptosis measured as enhanced PARP cleavage. In agreement with a sustained proliferative defect observed following dTRIM24 treatment, near-complete degradation of TRIM24 is observed in dTRIM24-treated cells throughout the duration of the experiment[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
1113.30 |
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Formula |
C55H68N8O13S2 |
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CAS 号 |
2170695-14-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (89.82 mM; Need ultrasonic) Ethanol : < 1 mg/mL (insoluble) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [2] |
MOLM-13 cells are seeded at 30,000 cells/well. Growth over time of MOLM-13 cells treated with 5 μM of indicated compounds (e.g., dTRIM24) over 7 d. At endpoints, cells are suspended and mixed with Viacount reagent at 1:3. The mixture is incubated for 5 min, and viable cells are counted on the Guava easycyte flow cytometer. Means from three technical replicates of cell counts are calculated[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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