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Calmidazolium chloride (Synonyms: R 24571) 纯度: 98.93%
Calmidazolium chloride (R 24571) 是一种钙调蛋白拮抗剂,拮抗CaM依赖性磷酸二酯酶和钙调蛋白诱导的红细胞Ca2+转运ATP酶活化, IC50 分别为0.15和0.35 μM。也用于抗癌研究。它结合CaMK的Kd 值为3 nM。
Calmidazolium chloride Chemical Structure
CAS No. : 57265-65-3
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥980 | In-stock | |
5 mg | ¥650 | In-stock | |
10 mg | ¥1000 | In-stock | |
50 mg | ¥2500 | In-stock | |
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200 mg | 询价 |
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Calmidazolium chloride 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Kinase Inhibitor Library
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- Autophagy Compound Library
生物活性 |
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds to CaMK with a Kd of 3 nM. |
IC50 & Target |
Kd: 3 nM (Calmodulin)[3] |
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体外研究 (In Vitro) |
Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[2]
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分子量 |
687.70 |
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Formula |
C31H23Cl7N2O |
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CAS 号 |
57265-65-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (145.41 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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