Desthiobiotin PEG DSPE

Desthiobiotin PEG DSPE:

DSPE PEG Desthiobiotin is one of Nanocs’ phospholipid PEG derivatives with a desthiobiotin tag. DSPE is an amphiphilic 18 carbon phospholipid existing in cell membranes and artificial liposomes. Desthiobiotin is a modified version of biotin. Compared to biotin, desthiobiotin binds to streptavidin, avidin or neutraviain with lower affinity and thus it can be eluted under milder conditions (i.e., by competitive displacement with regular, free biotin). As such, desthiobiotin reagent is a useful alternative to Biotin for avidin-biotin techniques in which nondenaturing elution of the labeled proteins is desired. DSPE modified PEG desthiobiotin has excellent amphiphilic property that can be incorporated into cell membranes, liposomes and other synthetic lipophilic nanoparticles. Resulted desthiobiotin can target avidin, streptavidin or neutravidin. PEG linker between DSPE and desthiobiotin tag offers better water solubility, less steric hindrance and enhanced stability.

Physical Properties:

• Off-white/white solid;
• Soluble in aqueous solution, DMSO or DMF;
• Functional group: desthiobiotin, DSPE;
• Reactive to: streptavidin, avidin;

Storage Conditions:

• Store at -20 ⁰C.