上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
IMR-1 纯度: 98.88%
IMR-1 是一种 Notch 抑制剂, IC50 为 26 μM。IMR-1 阻止 Maml1 募集到染色质上的 Notch 三元复合体 (NTC),抑制 Notch 靶基因转录,既有抗肿瘤活性。
IMR-1 Chemical Structure
CAS No. : 310456-65-6
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1050 | In-stock | |
5 mg | ¥550 | In-stock | |
10 mg | ¥950 | In-stock | |
50 mg | ¥3800 | In-stock | |
100 mg | ¥6300 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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IMR-1 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Neuronal Signaling Compound Library
- Stem Cell Signaling Compound Library
- Wnt/Hedgehog/Notch Compound Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
- Differentiation Inducing Compound Library
- Anti-Breast Cancer Compound Library
- Anti-Pancreatic Cancer Compound Library
- Angiogenesis Related Compound Library
- Transcription Factor Targeted Library
- Anti-Liver Cancer Compound Library
- Anti-Colorectal Cancer Compound Library
生物活性 |
IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth[1]. |
IC50 & Target |
IC50: 26 nM (Notch)[1] |
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体内研究 (In Vivo) |
IMR-1 (i.p.; 15mg/kg; for 28 days) inhibits Notch-dependent tumor growth in patient-derived xenograft models[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
353.41 |
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Formula |
C15H15NO5S2 |
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CAS 号 |
310456-65-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 100 mg/mL (282.96 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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