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GSK1904529A 纯度: 99.22%
GSK1904529A 是一种有效的,选择性的,具有口服活性和 ATP 竞争性的胰岛素样生长因子 1 受体 (IGF-1R) 和胰岛素受体 (IR) 抑制剂,IC50 值分别为 27 和 25 nM。GSK1904529A 在其他 45 种丝氨酸/苏氨酸和酪氨酸激酶中显示出较弱的活性 (IC50>1 μM)。GSK1904529A 具有抗肿瘤活性。
GSK1904529A Chemical Structure
CAS No. : 1089283-49-7
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1270 | In-stock | |
10 mg | ¥1350 | In-stock | |
50 mg | ¥3450 | In-stock | |
100 mg | ¥6250 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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GSK1904529A 相关产品
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生物活性 |
GSK1904529A is a potent, selective, orally active, and ATP-competitive inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), with IC50s of 27 and 25 nM, respectively. GSK1904529A shows poor activity (IC50>1 μM) in 45 other serine/threonine and tyrosine kinases. GSK1904529A exhibits anti-tumor activity[1][2]. |
IC50 & Target |
IC50: 27 nM (IGF-1R), 25 nM (IR)[1] |
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体外研究 (In Vitro) |
GSK1904529A displays high affinities for IGF-1R and IR, with Kis of 1.6 and 1.3 nM, respectively[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cycle Analysis[1]
Western Blot Analysis[1]
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体内研究 (In Vivo) |
GSK1904529A (30 mg/kg; p.o. once or twice daily for 21 d) has antitumor activity in mice[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
851.96 |
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Formula |
C44H47F2N9O5S |
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CAS 号 |
1089283-49-7 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (58.69 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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