三乙烯硫代磷酰胺
基本信息
| 产品名称 | 三乙烯硫代磷酰胺 |
|---|---|
| 英文名称 | Tri(1-aziridinyl)phosphine sulfide |
| 别名 | 塞替派； 硫次膦基三氮丙啶； 三胺硫磷； 三亚乙基硫代磷酰胺； 三(1-吖丙啶基)硫代磷酰；噻替派；N,N′,N″-三乙撑硫代磷酰胺； 噻替哌 |
| 英文别名 | Thio-TEPA;Triethylenethiophosphoramide;Thiofozil;Thiotef;Tio-tef;Tiofosfamid;Tiofosyl;Tiofozil;Tris(aziridinyl)phosphine sulfide;N,N′,N″-Triethylenethiophosphoramide |
| 规格或纯度 | 98% |
| 运输条件 | 冰袋运输 |
| 生化机理 | 该不稳定的氮碳基团会与 DNA 烷基化，从而导致不可逆的 DNA 损伤。它们通过使 DNA 双螺旋链中的鸟嘌呤核苷交联来阻止肿瘤生长、直接攻击 DNA。DNA 链无法解开和分离，从而阻止了细胞分裂。 |
一般描述
The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.
Thio-TEPA (N,N’N’-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to haematopoietic progenitor cell transplantation (HPCT).
The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.
Thio-TEPA (N,N’N’-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to haematopoietic progenitor cell transplantation (HPCT).
相关属性
| CAS编号 | 52-24-4 |
|---|---|
| 储存温度 | 2-8°C储存 |
| RTECS | SZ2975000 |
| MDL号 | MFCD00145452 |
| 分子量 | 189.22 |
| 分子式 | C6H12N3PS |
| EC号 | 200-135-7 |
| 品牌 | Jinpan |
| PubChem CID | 5453 |