棒曲霉素
基本信息
产品名称 | 棒曲霉素 |
---|---|
英文名称 | Patulin |
别名 | 4-羟基-4H-呋[3,2-c]吡喃-2(6H)-酮 |
英文别名 | 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one;Clavacin;Claviformin;Mycoin;Penicidin;Expansin;Leucopin;Gigantin |
应用 | An inhibitor of protein prenylation |
规格或纯度 | 99% |
运输条件 | 超低温冰袋运输 |
生化机理 | 真菌霉菌毒素,DNA破坏剂,诱导ROS产生。体外EGR-1依赖性ATF3上调诱导细胞凋亡。抗菌,致癌,诱变和抗癌剂。体内具有活性 |
一般描述
Patulin, a mycotoxin, has been reported to contain antibiotic characteristics. This compound displays the ability to specifically inhibit Na+-K+ ATPase. In murine studies, Patulin was found to inhibit protein prenylation in cells. Mechanistic studies sμggest that Patulin reduces incorporation of mevalonate into proteins and prevents protein transferase action, which is required for protein prenylation. Additional experiments show that this mycotoxin also inhibits cell-free microtubule polymerization by covalently reacting with thiol groups of microtubule proteins.An inhibitor of protein prenylation
Patulin, a mycotoxin, has been reported to contain antibiotic characteristics. This compound displays the ability to specifically inhibit Na+-K+ ATPase. In murine studies, Patulin was found to inhibit protein prenylation in cells. Mechanistic studies suggest that Patulin reduces incorporation of mevalonate into proteins and prevents protein transferase action, which is required for protein prenylation. Additional experiments show that this mycotoxin also inhibits cell-free microtubule polymerization by covalently reacting with thiol groups of microtubule proteins.
An inhibitor of protein prenylation
相关属性
CAS编号 | 149-29-1 |
---|---|
敏感性 | 对光敏感;对湿度敏感 |
熔点 | 108-111°C |
溶解性 | Soluble in water, 100% ethanol (25 mg/mL), ethyl acetate (50 mg/mL), amyl acetate, DMSO (10 mg/mL), acetone, ethyl ether (sparingly), benzene (sparingly), and dichloromethane (10 mg/mL) |
储存温度 | 避光,-20°C储存,干燥 |
MDL号 | MFCD00005858 |
密度 | 1.52 |
分子量 | 154.12 |
分子式 | C7H6O4 |
EC号 | 200-663-8 |
品牌 | Jinpan |
备注 | 如果有可能,您尽量在同一天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
PubChem CID | 4696 |