上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Thioridazine hydrochloride (Synonyms: 盐酸硫利达嗪;盐酸硫代利哒;甲硫达嗪盐酸盐;甲硫哒嗪盐酸盐) 纯度: 99.87%
Thioridazine hydrochloride 是一种具有口服活性的多巴胺受体 D2 家族蛋白的拮抗剂,具有有效的的抗焦虑活性。Thioridazine hydrochloride 也是一种有效的 PI3K-Akt-mTOR 信号通路的抑制剂,具有抗血管生成作用。Thioridazine hydrochloride 在多种类型的癌细胞中显示出抗增殖和凋亡诱导作用,对靶向癌症干细胞 (CSCs) 具有特异性。
Thioridazine hydrochloride Chemical Structure
CAS No. : 130-61-0
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥550 | In-stock | |
100 mg | ¥500 | In-stock | |
500 mg | ¥800 | In-stock | |
1 g | 询价 | ||
5 g | 询价 |
* Please select Quantity before adding items.
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生物活性 |
Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4]. |
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IC50 & Target |
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体外研究 (In Vitro) |
Thioridazine (0.01-100 μM; 48 h) reduces the cell viability of NCI-N87 and AGS cells in a concentration-dependent manner[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[1]
Western Blot Analysis[1]
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体内研究 (In Vivo) |
Thioridazine (25 mg/kg; i.p. every 3 days for 3 weeks) extends the survival of tumor-bearing mice and reduces the number of pluripotent embryonal carcinoma (EC) cells within tumors[5]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
407.04 |
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Formula |
C21H27ClN2S2 |
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CAS 号 |
130-61-0 |
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中文名称 |
盐酸硫利达嗪;盐酸硫代利哒;甲硫达嗪盐酸盐;甲硫哒嗪盐酸盐 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
H2O : 100 mg/mL (245.68 mM; Need ultrasonic) DMSO : ≥ 45 mg/mL (110.55 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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