Cas(579-13-5), 寡霉素A 来源于 淀粉酶产色链霉菌, Oligomycin A;MCH 32,Oligomycin A from Streptomyces diastatochromogenes,

发表于由

寡霉素A 来源于 淀粉酶产色链霉菌

大环内酯类抗生素。ATP合酶抑制剂。
≥97%

有货

Cas(579-13-5), 寡霉素A 来源于 淀粉酶产色链霉菌, Oligomycin A;MCH 32,Oligomycin A from Streptomyces diastatochromogenes,

CAS编号 579-13-5 | 品牌：Jinpan
Oligomycin A from Streptomyces diastatochromogenes

MSDS

质检证书(CoA)

相似产品

  • 分子式 C45H74O11
  • 分子量791.06
  • Beilstein号 5702132
  • EC号 209-437-3
  • MDL号 MFCD00065705
  • PubChem编号 5281899

货号 (SKU) 包装规格 是否现货 价格 数量
O102388-5mg 5mg 现货 Cas(579-13-5), 寡霉素A 来源于 淀粉酶产色链霉菌, Oligomycin A;MCH 32,Oligomycin A from Streptomyces diastatochromogenes,  
O102388-25mg 25mg 现货 Cas(579-13-5), 寡霉素A 来源于 淀粉酶产色链霉菌, Oligomycin A;MCH 32,Oligomycin A from Streptomyces diastatochromogenes,  

基本信息

产品名称 寡霉素A 来源于 淀粉酶产色链霉菌
英文名称 Oligomycin A from Streptomyces diastatochromogenes
别名 Oligomycin A;MCH 32
英文别名 MCH 32
规格或纯度 ≥97%
运输条件 超低温冰袋运输
生化机理 Oligomycin inhibits membrane bound mitochondrial ATP synthase (ATPase), proton channel (pump, FO subunit) blockers thereby inhibiting oxidative phosphorylation and the electron transport chain.Macrolide antibiotic. ATP synthase inhibitor. Blocks the proton channel (Fo subunit) to uncouple oxidative phosphorylation. Shows antitumor activity. Active in vivo .

一般描述

Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. This compound stimulates lysosome acidification due to shunting of membrane potential at a concentration of 1.5-3 μM. The compound has been observed to Induce apoptosis in a variety of cell types along with inducing a switch from the apoptotic to necrotic pathway. It also exhibits broad nematocidal, antifungal, and antitumor activities. Oligomycin A has caused dissipated mitochondrial membrane potential, decreased cytoplasmic ATP contents and disassembled metaphase II oocyte spindles when introduced to mouse oocytes.Oligomycin is used to inhibit membrane bount mitochondrial ATP synthase. It is used to inhibit sucrose synthesis and 14C translocation in sunflower leaves, to study antibiotic resistance, and to study carotid chemoreceptor responses to O2 and CO2 in the cat.

Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. This compound stimulates lysosome acidification due to shunting of membrane potential at a concentration of 1.5-3 μM. The compound has been observed to Induce apoptosis in a variety of cell types along with inducing a switch from the apoptotic to necrotic pathway. It also exhibits broad nematocidal, antifungal, and antitumor activities. Oligomycin A has caused dissipated mitochondrial membrane potential, decreased cytoplasmic ATP contents and disassembled metaphase II oocyte spindles when introduced to mouse oocytes.
Oligomycin is used to inhibit membrane bount mitochondrial ATP synthase. It is used to inhibit sucrose synthesis and 14C translocation in sunflower leaves, to study antibiotic resistance, and to study carotid chemoreceptor responses to O2 and CO2 in the cat.

相关属性

CAS编号 579-13-5
溶解性 Soluble in DMSO (300 mg/ml), ethanol (200 mg/ml), acetone (800 mg/ml), glacial acetic acid (37.5 g/100ml) at 25 °C, water (2 mg/100ml) at 25 °C, ether (28 g/100ml) at 25 °C, and benzene (6 g/100ml) at 25 °C.
储存温度 -20°C储存
RTECS RK3328000
MDL号 MFCD00065705
密度 1.14
分子量 791.06
分子式 C45H74O11
EC号 209-437-3
品牌 Jinpan
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PubChem CID 5281899