无活菌素 来源于灰色链霉菌变种
基本信息
| 产品名称 | 无活菌素 来源于灰色链霉菌变种 |
|---|---|
| 英文名称 | Nonactin from Streptomyces griseus var griseus |
| 别名 | 铵离子载体 |
| 英文别名 | Ammonium Ionophore; Werramycin-A; Polynactin |
| 规格或纯度 | 96%（A mixture of Nonactin, Monactin and Dinactin） |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is a uncoupler of oxidative phosphorylation.Selective K + and NH 4 + monovalent cation ionophore. Antibiotic agent. Induces cation transport across artificial membranes. Inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents. Shows antibiotic effects in vivo. |
一般描述
Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on requestNonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drμg-resistant cancer cells. Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is used in urea and ammonium specific electrodes.
Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on request
Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells. Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is used in urea and ammonium specific electrodes.
相关属性
| CAS编号 | 6833-84-7 |
|---|---|
| 敏感性 | 对湿度敏感 |
| 熔点 | 145℃-146℃ |
| 溶解性 | Soluble in chloroform (9.80 – 10.20 mg/ml), ethanol (10 mM), DMSO (10 mg/ml), and methanol. Insoluble in water. |
| 储存温度 | -20°C储存,充氩 |
| 分子量 | 736.93 (for Nonactin) |
| 分子式 | C40H64O12 |
| 品牌 | Jinpan |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 72519 |