Cas(50-65-7), 氯硝柳胺, 2',5-二氯-4'-硝基水杨酸酰替苯胺;4'-硝基-2',5-二氯水杨酰苯胺;百螺杀;见螺杀;血防-67;灭绦录,Niclosamide,

发表于由

氯硝柳胺

抗蠕虫药，抗癌药和质子试剂。STAT3抑制剂。
98%

有货

Cas(50-65-7), 氯硝柳胺, 2',5-二氯-4'-硝基水杨酸酰替苯胺;4'-硝基-2',5-二氯水杨酰苯胺;百螺杀;见螺杀;血防-67;灭绦录,Niclosamide,

CAS编号 50-65-7 | 品牌：Jinpan
Niclosamide

MSDS

质检证书(CoA)

相似产品

  • 分子式 C13H8Cl2N2O4
  • 分子量327.12
  • Beilstein号 2820605
  • EC号 200-056-8
  • MDL号 MFCD00057597
  • PubChem编号 4477

货号 (SKU) 包装规格 是否现货 价格 数量
N130841-5g 5g 现货 Cas(50-65-7), 氯硝柳胺, 2',5-二氯-4'-硝基水杨酸酰替苯胺;4'-硝基-2',5-二氯水杨酰苯胺;百螺杀;见螺杀;血防-67;灭绦录,Niclosamide,  
N130841-25g 25g 现货 Cas(50-65-7), 氯硝柳胺, 2',5-二氯-4'-硝基水杨酸酰替苯胺;4'-硝基-2',5-二氯水杨酰苯胺;百螺杀;见螺杀;血防-67;灭绦录,Niclosamide,  
N130841-50g 50g 现货 Cas(50-65-7), 氯硝柳胺, 2',5-二氯-4'-硝基水杨酸酰替苯胺;4'-硝基-2',5-二氯水杨酰苯胺;百螺杀;见螺杀;血防-67;灭绦录,Niclosamide,  
N130841-250g 250g 现货 Cas(50-65-7), 氯硝柳胺, 2',5-二氯-4'-硝基水杨酸酰替苯胺;4'-硝基-2',5-二氯水杨酰苯胺;百螺杀;见螺杀;血防-67;灭绦录,Niclosamide,  
N130841-500g 500g 现货 Cas(50-65-7), 氯硝柳胺, 2',5-二氯-4'-硝基水杨酸酰替苯胺;4'-硝基-2',5-二氯水杨酰苯胺;百螺杀;见螺杀;血防-67;灭绦录,Niclosamide,  

基本信息

产品名称 氯硝柳胺
英文名称 Niclosamide
别名 2′,5-二氯-4′-硝基水杨酸酰替苯胺
英文别名 2′,5-Dichloro-4′-nitrosalicylanilide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
规格或纯度 98%
运输条件 常规运输
生化机理 抗蠕虫药，抗癌药和质子试剂。STAT3抑制剂（IC 50 = 0.25μM）。已显示抑制许多下游信号传导途径，包括mTORC1，Wnt /β-catinin，NF-κB，Notch和ROS。

一般描述

Niclosamide is an inhibitor of the Stat3 signaling pathway. Niclosamide inhibits the activation, nuclear translocation and transactivation of Stat3. Niclosamide displays selectivity for Stat3 over Stat1, Stat5, JAK1, JAK2 and Src kinases. Niclosamide inhibits the transcription of Stat3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active Stat3. Niclosamide is also a FRAP inhibitor via reversible inhibition of mTORC1 signaling and stimulates autophagy in vitro. Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.An inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor.

Niclosamide is an inhibitor of the Stat3 signaling pathway. Niclosamide inhibits the activation, nuclear translocation and transactivation of Stat3. Niclosamide displays selectivity for Stat3 over Stat1, Stat5, JAK1, JAK2 and Src kinases. Niclosamide inhibits the transcription of Stat3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active Stat3. Niclosamide is also a FRAP inhibitor via reversible inhibition of mTORC1 signaling and stimulates autophagy in vitro. Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.
An inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor.

相关属性

CAS编号 50-65-7
熔点 225-230°C
溶解性 Soluble in ethanol (25 mM), DMSO (10 mM), chloroform (very slightly), and methanol: acetone (1: 1) (50 mg/ml). Insoluble in water.
RTECS VN8400000
MDL号 MFCD00057597
密度 1.161
分子量 327.12
分子式 C13H8Cl2N2O4
EC号 200-056-8
品牌 Jinpan
备注 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
PubChem CID 4477